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Estro Flavone

0.15 LBS
Calculated at checkout

Product Description

Healthy Hormone Balance for Women of All Ages*
• Promotes healthy hormone balance, especially estrogen metabolism and detoxification, in women of all ages*
• Effectively modulates overall estrogenic activity to help provide significant relief from common symptoms of PMS (premenstrual syndrome) such as cramping, irritability and breast tenderness, as well as symptoms of perimenopause and menopause such as hot flushes, occasional mood swings and sleep imbalances*
• Helps eliminate undesirable estrogen mimics locked in hormone and neurological receptor sites*
• Promotes preferred pathways of estrogen metabolism, including the conversion of estradiol to 2-hydroxyestrone, a weaker estrogen that may help protect estrogen-sensitive tissues* 


Healthy Hormone Support For Women of All Ages*
Targeted Nutritional Support for Healthy Hormone Balance. Premier Estro Complex promotes healthy hormone balance in women of all ages by featuring a broad range of targeted nutrients and synergists that support healthy estrogen metabolism and detoxification.* For women with hormone-related health concerns, supporting optimal hormone balance may provide relief and may result in improvement in common symptoms of PMS (premenstrual syndrome), perimenopause, and menopause.

Comprehensive Formula Design
What makes this formula unique is that the synergism of its broad-range nutrients address multiple concerns related to hormone balance with special emphasis on estrogen activity and metabolism. Because it exerts multiple influences, Premier Estro Complex is an excellent choice for a variety of women’s concerns. Its hormone-balancing support may provide relief for women with estrogen-excess concerns as well as providing effective nutritional support to encourage healthy estrogen balance in menopausal women.*

Estrogen Metabolism
To enable its detoxification, estrogen goes through a process called hydroxylation that yields the so-called “good” 2-hydroxyestrone (2-OH) estrogen and the less desirable 16-hydroxyestrone (16-OH) and 4-hydroxyestrone (4-OH) estrogens. Because these estrogen metabolites vary greatly in their level of estrogenic activity, their ultimate effect on the body’s tissues (whether beneficial or stressful) depends on how they are processed in the body.
The 2-OH estrogen has weak estrogenic activity, while 4-OH and 16-OH estrogens show long-acting estrogenic activity and are often associated with estrogen-excess related health concerns. Both 2-OH and 4-OH estrogens (called catechol estrogens) can be readily oxidized to quinones, which are highly reactive and can damage DNA.
However, this oxidation process can be altered if the catechol estrogens are first detoxified via Phase II liver detoxification (methylation). Therefore, the goal is to achieve an adequate nutritional status so that the liver can easily render 4-OH less reactive, while supporting the beneficial properties of 2-OH. Thus, we can see that supporting the liver detoxification pathway is a critical factor in supporting overall healthy estrogen activity.


Selective Estrogen Receptor Modulators (SERMs)
SERMs (selective estrogen receptor modulators) are non-steroidal compounds that do not contain actual estrogen hormones and are not considered to be hormones. However, these compounds are capable of binding to estrogen receptors and influencing their activities. SERMs are called “selective” because they can have estrogen-like effects on certain cells (i.e. turn on the cell’s estrogen receptor) or they can block the effects of estrogen on other cells (i.e. turn off the receptor).
In a woman with low estrogen levels, SERMs can help increase estrogen response by turning on receptors, such as during menopause – whereas in cases of high estrogen levels, SERMs help turn off estrogen receptors. SERMs support a moderate level of estrogen activity; when binding to the estrogen receptors, they can inhibit endogenous estrogen when too much is present, but at the same time, also support estrogen’s many important functions, especially for the heart, uterus, breast, vagina and bone.

Key Ingredients
Natural SERMs: Isoflavones, Red Clover and DIM(Diindolylmethane)

Isoflavones (from fermented non-GMO soy) In Premier Estro Complex, we use the preferred form of isoflavones from nonGMO Asian soy that has been traditionally fermented. The fermentation process converts glycone forms of isoflavones into the aglycone form – which are absorbed much more completely and quickly, and are the most effective form of the Isoflavone molecule. Soy isoflavones that have not been fermented are more difficult to digest and do not offer genistein, a key isoflavone, in its readily available form. After fermentation, major available isoflavones are genistein, daidzein, and glycitein.
Both fermented soy isoflavones and red clover isoflavones can act as SERMs that can support healthy levels of sex hormone binding globulin (SHBG), which may also support balanced estrogenic activity since only unbound estrogens can enter target-tissue cells. In addition, isoflavones have shown an ability to promote production of the “good” 2-OH estrogen over the less desirable 16-OH and 4-OH estrogens. The North American Menopause Society suggests that soy isoflavones can be a natural alternative to synthetic estrogen therapy for relief of mild menopausal symptoms such as hot flashes and night sweats. Isoflavones may help offset the drop in estrogen and regulate its fluctuations that occur at menopause. Isoflavone research also shows great promise for serious concerns of the breast, prostate, colon, lung, blood and skin.

Isoflavones also play an important role in protecting and maintaining strong, healthy bones. Evidence shows that genistein and daidzein help conserve bone mass. Independent studies conducted at the University of Illinois and the University of Hong Kong concluded that consuming soy isoflavones helps increase bone mineral content and bone density. Another study at the University of Texas suggested that isoflavones may also stimulate bone formation. By preserving bone mass and stimulating bone turnover, researchers noted the potential role of soy isoflavones in maintaining bone health during and after menopause.

Red Clover Isoflavones. Research shows that red clover isoflavones have also been shown to support healthy arterial function and heart health; promote healthy bone metabolism and help provide significant relief from common symptoms of menopause such as hot flashes, occasional mood swings and sleep imbalances.*

DIM (Diindolylmethane).
Research shows that DIM also helps balance estrogen metabolism. Over 40 studies on DIM are on file in the National Library of Medicine database. DIM has proven to be an efficient way to help increase the ratio of estrogen metabolites in favor of the “good” estrogen. In addition to its estrogen balancing effect, DIM helps stimulate progesterone production and competes with testosterone for protein binding.
This helps to maintain testosterone in its free form (the most de-sirable form). DIM helps reduce the conversion of testosterone to estrogen.
Due to the aging process (especially prevalent when coupled with obesity or regular alcohol use), estrogen metabolism is reduced. DIM promotes healthy estrogen metabolism and helps to improve symptoms of menopause or PMS. As little as 0.5mg/kg body weight/day of DIM has been demonstrated as an effective dose. That means, for a 150 lb person, only 30 mg/day would be needed. DIM is also very effective when used in conjunction with other phytoestrogens such as isoflavones.

Resveratrol and Chrysin.
Resveratrol is a proven bioflavonoid found in grapes and certain plants (such as giant knot weed). It has been classified as a SERM based on its ability to bind to estrogen receptors and act as both an estrogen agonist and antagonist. Resveratrol provides many other benefits, including cardioprotective properties.(12) Chrysin is a bioflavonoid that has been shown to inhibit the activity of aromatase, an enzyme that synthesizes estrogen from androgens.(13) Aromatase is found in fat cells, including breast tissue; its inhibition may be useful in inhibiting the cell-proliferative effects of estrogen.

European Rosemary Leaf Concentrate.
Research shows that the herb rosemary (Rosmarinus officinalis) helps enhance production of 2-OH estrogen (the “good” estrogen) while inhibiting the production of the “bad” estrogen, 16-OH, and in general, enhances estrogen detoxification. In particular, rosemary concentrate shows in vitro evidence of supporting healthy breast tissue.

Chinese, Nonpesticided Royal Jelly.
Royal jelly is one of the world’s most complete, natural super nutrient concentrates (unfortunately, most sources are highly pesticided from worker bees working in pesticided fields). Royal jelly is the main source of food for the queen bee which has a life span up to 50 times longer than the worker bees. Royal jelly is rich in all of the essential B vitamins, along with natural vitamins A, C, D, E and K, more than 12 important minerals, 18 amino acids, acetylcholine (a neurotransmitter), lecithin and many other constituents.
Royal jelly is an effective anti-aging tonic with a full repertoire of master nutrients necessary to sustain life, promote longevity and vigor. Its helps to provide a feeling of well being and to promote youthfulness. Research shows that royal jelly not only promotes anti-aging and longevity, but also exerts beneficial effects on almost every body tissue as well as balancing estrogen and overall hormone metabolism. It is excellent help during pregnancy, PMS or mild menopause symptoms such as hot flashes, mood swings, night sweats and feeling “blue.” Research also supports royal jelly’s role in memory function, liver support (cholesterol), heart and circulation efficiency, skin beauty and much more.

Central American Nopal Cactus.
The use of Nopal (commonly known as the prickly pear) dates back to the Aztec period in Mexico (around 900 AD). Nopal is highly nutritious and contains a unique phytochemical, vitamin and mineral profile that contributes to its many beneficial effects. Studies show Nopal’s valuable role in promoting hormone and glandular balance. It benefits the pancreas and liver, both vitally important in maintaining blood sugar levels, triglycerides and cholesterol levels within the normal range, by helping to metabolize fat and fatty acids and eliminating excess bile acids (excess bile acid is eventually converted into cholesterol).
Nopal’s pectins, lignans (natural fiber) and mucilage benefit the digestive and intestinal systems, including constipation. Nopal also aids in the balancing the nervous system, which benefits the body’s overall function. Studies have shown that Nopal also helps improve the function of the immune system.
Nopal’s many bodily effects are due in part to its abundance of essential nutrients, including polysaccharides, fiber, bioflavonoids, natural vitamins, including beta-carotene (A), B1, B2, B3, and C; natural minerals including potassium, calcium, magnesium and iron, and 18 amino acids (8 which are essential) in an easily digestible form.

Other Nutritional Synergists.
Additional synergists and co-factors of this formula include European Beta-Sitosterol and sterolins (phytosterols) which appear to act either as weak forms of estrogen stimulators (agonist receptor-site action - when estrogen levels are declining) or protectors against higher levels of estrogens by competitive inhibition (antagonist receptor-site action). The next synergist, unheated, nonirradiated North Atlantic kelp, supports the thyroid’s regulation of oxygen uptake at the cell level, which is critical for detoxification of the reproductive organs and the liver.
Marine coral mineral concentrate boosts tissue oxygen levels and cellular oxygen availability to support alkaline pH levels for best tissue function.Natural-source free-form amino acids (rice source) which are highly biologically available (over 95% are free form) are the perfect co-factor/ transporter for the broad spectrum of botanical agents in this formula.Bromelain and papain are protein-digesting enzymes from pineapple and papaya fruit, assisting uptake of nutrients and aiding pain relief, especially during PMS and menopause. A full-spectrum of highly purified plantenzymes (protease, lipase, amylase, cellulase, invertase, lactase, maltase) function as critical co-factors and transporters of all the nutraceutical compounds in this formula.

Supplement Facts
Serving Size: 1 capsule
Servings Per Container: 60
Proprietary Formula…………480mg*
free-form amino acids (rice source), nopal cactus (pad) (opuntia ficus-indica), beta-sitosterol, toyal jelly concentrate (6%), DIM (diindolylmethane), red clover (blossom) (Trifolium pra.), isoflavones (fermented concentrate, non-GMO soy source), marine coral concentrate, chrysin, quercetin,  rosemary leaf extract (Rosmarinus off.), kelp (fronds) (Laminaria dig.), bromelain enzymes (from pineapple), papain enzymes (rome papaya), resveratrol (derived from giant knot weed), noni (fruit, seed) (morinda cit.), amylase, maltase, apple cider vinegar, protease, plant-source pepsin, lipase, lactase, invertase, cellulase
Other Ingredients: vegetable cellulose capsule
*Daily Value Not Established

Recommended Use
Adults or children (age 4 and up): Take 1 capsule, 3 times daily. For special programs recomended by your practitioner, up to 12 individual servings may be taken daily (1 serving = 1 capsule).

*Disclaimer:  The FDA has not evaluated any of these statements. This product is not intended to diagnose, treat, cure or prevent any disease.


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